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  <xs:element id="zts_Zts_FixedtoFloatInterestRateSwapMember" abstract="true" name="Zts_FixedtoFloatInterestRateSwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_InternationalMember" abstract="true" name="InternationalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_ScheduleOfIndefinitelivedAndFinitelivedIntangibleAssetsTable" abstract="true" name="ScheduleOfIndefinitelivedAndFinitelivedIntangibleAssetsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="zts_ProductRightsMember" abstract="true" name="ProductRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems" abstract="true" name="FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="zts_PeerCompaniesMember" abstract="true" name="PeerCompaniesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGradedVestingPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGradedVestingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="zts_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsTargetNumberofUnitsPercentage" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsTargetNumberofUnitsPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="zts_August2024ShareRepurchaseProgramMember" abstract="true" name="August2024ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_UlianopolisBrazilMember" abstract="true" name="UlianopolisBrazilMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_LossContingencyAdditionalNumberOfDefendants" abstract="false" name="LossContingencyAdditionalNumberOfDefendants" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="zts_LawsuitTemporarilySuspended" abstract="false" name="LawsuitTemporarilySuspended" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="zts_GrossMargin" abstract="false" name="GrossMargin" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="zts_BusinessCombinationAcquisitionAndDivestureRelatedCosts" abstract="false" name="BusinessCombinationAcquisitionAndDivestureRelatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zts_AcquisitionAndDivestitureDepreciationDepletionAndAmortization" abstract="false" name="AcquisitionAndDivestitureDepreciationDepletionAndAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zts_CertainSignificantReconcilingItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest" abstract="false" name="CertainSignificantReconcilingItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zts_CertainSignificantReconcilingItemsIncludedinDepreciationDepletionandAmortization" abstract="false" name="CertainSignificantReconcilingItemsIncludedinDepreciationDepletionandAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zts_OtherUnallocatedItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest" abstract="false" name="OtherUnallocatedItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zts_OtherUnallocatedItemsIncludedinDepreciationDepletionandAmortization" abstract="false" name="OtherUnallocatedItemsIncludedinDepreciationDepletionandAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zts_KristinPeckMember" abstract="true" name="KristinPeckMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_KristinPeckTradingArrangementCommonStockMember" abstract="true" name="KristinPeckTradingArrangementCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zts_KristinPeckTradingArrangementCommonStockUponExerciseOfStockOptionsMember" abstract="true" name="KristinPeckTradingArrangementCommonStockUponExerciseOfStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
